Publications, Datasets, & Reagents

  • Restoration of Fbxo7 expression in dopaminergic neurons restores tyrosine hydroxylase in a mouse model of Parkinson’s disease. Al Rawi S, Tyers P, Barker RA, Laman H. biorxiv 2024 Oct. Link.

  • Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co-regulate proteasomes and mitochondria. Al Rawi S*, Simpson L*, Agnarsdóttir G, McDonald NQ, Chernuha V, Elpeleg O, Zeviani M, Barker RA, Spiegel R^, Laman H.^ FEBS J 2024 Feb. Link.

    • Comment on our article. Link.

  • Development of constrained peptide inhibitors targeting an oncogenic E3 ubiquitin ligase. Zenkevičiūtė G, Xu W, Iegre J, Seki H, Tan YS, Rowling PJE, Ferrer F, Verma C, Spring DR, Laman H, Itzhaki LS. biorxiv 2023 May. Link

  • E3 Ubiquitin Ligases: From Structure to Physiology to Therapeutics, Volume II. Licchesi J, Laman H, Ikeda F, Ferguson F. Bolanos-Garcia V. Front Physiol. 2022. doi.org/10.3389/fphys.2022.1038793 . eCollection. Link.

  • Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells. Harris R, Yang M, Schmidt C, Royet C, Singh S, Natarajan A, Morris M, Frezza C, Laman H. J Cell Biol. 2022 Jun 7. doi: 10.1083/jcb.202203095. Link. Spotlight on our article. Link.

    • J Cell Biol: Article Spotlight: Ubiquitinating the way to T cell metabolism. McPhedran S & Lum J. 2022 Jun 13. Link.

    • Metabolomics dataset available on Metabolomics Workbench. Link .Study ID ST001986 (DatatrackID:2912).

  • A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells. Shen JZ, Qiu Z, Wu Q, ZhangG, Harris R, Sun D, Rantala J, Barshop WD, Zhao L, Lv D, Won KA, Wohlschlegel J, Sangfelt O, Laman H, Rich JN, Spruck C. Mol Cell. Mar 17;82(6):1123-1139.e8. doi: 10.1016/j.molcel.2022.01.022. Epub 2022 Feb 18. Link.

  • Laman Lab Plamids available on Addgene! Link.

  • Analysis of the FBXO7 promoter reveals overlapping Pax5 and c-Myb binding sites functioning in B cells. Harris R, Randle SJ, Laman H. Biochem Biophys Res Comm 2021 Mar 11.doi: 10.1016/j.bbrc.2021.03.052. Epub 2021 Mar 25. Link.

  • The FBXL family of F-box proteins: variations on a theme. Mason BJ & Laman H. Open Biol. 2020 Nov;10(11):200319. doi: 10.1098/rsob.200319. Epub 2020 Nov 25. Link.

  • E3 Ubiquitin Ligases: From Structure to Physiology. Licchesi JDF, Laman H, Ikeda F, Bolanos-Garcia VM. Front Physiol. 2020. Nov 26;11:621053. doi: 10.3389/fphys.2020.621053. eCollection.. Link.

  • The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-kappa B signaling pathway. Spagnol V, Oliveira CAB, Randle SJ, Passos PMS, Correia CRSTB, Simaroli NB, Oliveira JS, Mevissen TET, Medeiros AC, Gomes MD, Komander D, Laman H, Teixeira FR. Biochim Biophys Acta. 2020 Sep 30;1865(1):129754. doi: 10.1016/j.bbagen.2020.129754. Link.

  • Nedd8 hydrolysis by UCH proteases in Plasmodium parasites. Karpiyevich M, Adjalley S, Mol M, Ascher DB, Mason B, van der Heden van Noort GJ, Laman H, Ovaa H, Lee MCS, Artavanis-Tsakonas K. PLoS Pathog. 2019 Oct 28;15(10):e1008086. doi: 10.1371/journal.ppat.1008086. Link. PDF.

  • A conserved requirement for Fbxo7 during male germ cell cytoplasmic remodelling. Rathje CC, Randle SJ, Al Rawi S, Skinner BM, Rajamundar A, Nelson DE, Johnson EEP, Bacon J, Vlazak M, Affara NA, Ellis PJ, Laman H. Front Physiol. 2019. Oct 10;10:1278. doi: 10.3389/fphys.2019.01278. Link. PDF.

  • Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation. Mason B, Flach S, Teixeira, FR, Manzano Garcia R, Rueda OM, Abraham JE, Caldas C, Edwards PAW. Laman H. Cell Mol Life Sci. 2019 Sept 27. Link. PDF.

  • Loss of FBXO7 results in a Parkinson’s-like dopaminergic degeneration via an RPL23-MDM2-TP53 pathway. Stott SRW*, Randle SJ*, al Rawi S, Rowicka PA, Harris R, Mason B, X.ia J, Dalley, JW, Barker RA, Laman H. J Pathol. 2019 Oct;249(2):241-254. Link. PDF.

  • Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27. Patel SP, Randle SJ, Gibbs S, Cooke A, Laman H. Cell Mol Life Sci. 2017 Apr;74(8):1553-1566 . Link. PDF

  • Structure and function of Fbxo7/PARK15 in Parkinson's disease. Randle SJ, Laman H. Curr Protein Pept Sci. 2017;18(7):715-724. Link. PDF.

  • Gsk3β and Tomm20 are substrates of the SCF-Fbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. Teixeira FR^, Randle SJ^, Patel SP^, Mevissen TE, Zenkeviciute G, Koide T, Komander D, Laman H. Biochem J. 2016 Oct 15;473(20):3563-3580. ^First author. Link. PDF. Supp.

  • F-box protein interactions with the hallmark pathways in cancer. Randle SJ, Laman H. Semin Cancer Biol. 2016 Feb;36:3-17. Link. PDF.

  • Defective erythropoiesis in a mouse model of reduced Fbxo7 expression due to decreased p27 expression. Randle SJ, Nelson DE, Patel SP, Laman H. J Pathol. 2015 Jun;237:263-272. Link. PDF. Supp.

  • Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins. Nelson DE, Randle SJ, Laman H. Open Biol. 2013 Oct 9;3(10):130131. Link. PDF.

  • The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Burchell VS^, Nelson DE^, Sanchez-Martinez A^, Delgado-Camprubi M, Ivatt RM, Pogson JH, Randle SJ, Wray S, Lewis PA, Houlden H, Abramov AY, Hardy J, Wood NW, Whitworth AJ*, Laman H*, Plun-Favreau H*. Nat Neurosci. 2013 Sep;16(9):1257-65. ^First author; *Senior corresponding author. Link. PDF.

    • Comment: Daily Mail. Link

    • Comment: University of Cambridge press release. Link

    • Comment: Alzheimer's Forum. Link

    • Comment: Recommended on F1000

    • Comment: Parkinson's News Today. Link.

    • Highlight: Degenerating Neurons. Link.

  • Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling. Kuiken HJ, Egan DA, Laman H, Bernards R, Beijersbergen RL, Dirac AM. J Cell Mol Med. 2012 Sep;16(9):2140-9. Link. PDF.

  • Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNA. Gooding M, Tudzarova S, Worthington RJ, Kingsbury SR, Rebstock AS, Dube H, Simone MI, Visintin C, Lagos D, Quesada JM, Laman H, Boshoff C, Williams GH, Stoeber K, Selwood DL. Chem Biol Drug Des. 2012 Jan;79(1):9-21. Link. PDF.

  • Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis. Lomonosov M, Meziane el K, Ye H, Nelson DE, Randle SJ, Laman H. PLoS One. 2011;6(6):e21165. Link. PDF.

  • Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells. Meziane el K^, Randle SJ^, Nelson DE, Lomonosov M, Laman H. J Cell Sci. 2011 Jul 1;124(Pt 13):2175-86. ^First author. Link. PDF.

  • A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteins. Nelson DE, Laman H. J Biol Chem. 2011 Jun 3;286(22):19804-15. Link. PDF.

  • Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane el K, McDonald NQ. J Biol Chem. 2008 Aug 8;283(32):22325-35. Link. PDF

  • Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells.Okuyama M^, Laman H^, Kingsbury SR^, Visintin C, Leo E, Eward KL, Stoeber K, Boshoff C, Williams GH, Selwood DL. ^First author. Nat Methods. 2007 Feb;4(2):153-9. Link. PDF

    • Comment: Research highlights in Nature. Link.

    • Comment: Spotlight in ACR Chemical Research. Link.

  • Fbxo7 gets proactive with cyclin D/cdk6. Laman H. Cell Cycle. 2006 Feb;5(3):279-82. Link. PDF.

  • Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. Laman H, Funes JM, Ye H, Henderson S, Galinanes-Garcia L, Hara E, Knowles P, McDonald N, Boshoff C. EMBO J. 2005 Sep 7;24(17):3104-16. Link. PDF.

  • Regulation of growth signalling and cell cycle by Kaposi's sarcoma-associated herpesvirus genes. Direkze S, Laman H. 2004 Dec;85(6):305-19. Link. PDF.

  • RNA interference: a potential tool against Kaposi's sarcoma-associated herpesvirus. Godfrey A, Laman H, Boshoff C. Curr Opin Infect Dis. 2003 Dec;16(6):593-600. Link.

  • Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Coverley D, Laman H, Laskey RA. Nat Cell Biol. 2002 Jul;4(7):523-8. Link. PDF

  • Cyclin-mediated export of human Orc1. Laman H, Peters G, Jones N. Exp Cell Res. 2001 Dec 10;271(2):230-7. Link. PDF

  • Is KSHV lytic growth induced by a methylation-sensitive switch? Laman H, Boshoff C. Trends Microbiol. 2001 Oct;9(10):464-6. Link. PDF.

  • Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication. Laman H, Coverley D, Krude T, Laskey R, Jones N. Mol Cell Biol. 2001 Jan;21(2):624-35. Link. PDF.

  • Crystal structure of a gamma-herpesvirus cyclin-cdk complex. Card GL, Knowles P, Laman H, Jones N, McDonald NQ. EMBO J. 2000 Jun 15;19(12):2877-88. Link. PDF.

  • Viral-encoded cyclins. Laman H, Mann DJ, Jones NC. Curr Opin Genet Dev. 2000 Feb;10(1):70-4. Link. PDF.

  • Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus.Mann DJ, Child ES, Swanton C, Laman H, Jones N. EMBO J. 1999 Feb 1;18(3):654-63. Link. PDF.

  • Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae. Laman H, Balderes D, Shore D. Mol Cell Biol. 1995 Jul;15(7):3608-17. Link. PDF.

  • Identification of a nitrogen-regulated promoter controlling expression of Klebsiella pneumoniae urease genes. Collins CM, Gutman DM, Laman H. Mol Microbiol. 1993 Apr;8(1):187-98. Link.